It is not possible to achieve large success without hardships and setbacks. But it is possible to live the rest of your life without defeat. Big thinkers react to setbacks this way: Regard the setback as a lesson. Learn from it. Research it Use it to propel you forward. Salvage something from every setback.
Blend persistence with experimintation. Back off and start afresh with a new approach.
Think Big Enough to see that defeat is a state of mind, nothing more.